Description

From the study for physical properties and dissolution profile of tablets it can concluded that the dissolution of drugs increased with increase in concentration of superdisintegrant (crosscarmellose sodium). The difference was observed in dissolution profile between tablets containing different concentration of disintegrantsThe evaluated tablet passed all the various quality control checks. The formulation containing Cross Povidone 12-CL also passed the quality control checks but dissolution of the formulation was found to be less as compared to formulation containing crosscarmellose sodium. Both these formulations were found suitable for formulating the tablet and were stable during the stability studies. But from both formulations in term of drug release the formulations F6 with Cross Carmellose Sodium was found to be better.The above findings showed the need of superdisintegrants for better dissolution of poorly soluble drugs.