Description

High-throughput and high-content analysis of cultured cells or even small organisms are of imminent importance in drug discovery, toxicology and in individualized medicine. In medicine, the identification of tailored patient-specific therapy is important in cancer, chronic inflammation, infection and other diseases. High Content Screening was developed with the perspective of the history of the development of the automated DNA sequencers that revolutionized the field of genomics. Furthermore, HCS was based on a history of important developments in modern cytology. Cell damage caused by free radicals appears to be a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, cataracts, immune system decline, and brain dysfunction Overall, free radicals have been implicated in the pathogenesis of at least 50 diseases.