Description

Irritable Bowel Syndrome and Inflammatory Bowel Diseases , including Crohn's disease and Ulcerative colitis, are two of the leading causes of chronic intestinal conditions in the world. Ulcerative colitis as an Inflammatory bowel disease is characterized by strong activation of the mucosa associated immune system due to a complex interaction of genetic, immunological and environmental factors .It is well established that the composition of the intestinal microbial flora has an impact on host immunity and influences the coarse of mucosal inflammation .Several immunological mucosal abnormalities have been described in ulcerative colitis patients and these can be grouped into those that involve the epithelial barrier, those that involve the innate immune response (nonspecific defense against pathogens by phagocytes, dendritic cells). Although IBDS was seen as a complex biopsychological condition in which a number of major mechanisms at the central and peripheral level interact alteration has been directed to the putative role of low-grade mucosal inflammation, on the basis of evidences showing that some patients with IBDS have an increased number of inflammation.